| EMMA ID | common strain name(s) | targeted (or) expressed gene(s) (click on the name to search the allele or transgene description(s) in the Mouse Genome Database) | mutation (sub)type | (International) Strain Designation | click to order/register an interest |
| EM:01256 | Smu del | immunoglobulin heavy chain complex | targeted/knock-out | B6.129S2/Sv-Ightm2Cog/Orl | order |
Genetic background : 129
Phenotype description: decreased class switching to all immunoglobulin isotypes.
Genetic description: Targeting construct is derived from 129 DNA. The deletion spans all the repeats known in the Emu-Cmu intron leaving intact the necessary elements for accurate splicing of mu transcripts.
Original Producer: KHAMLICHI Ahmed Amine.
References:
- Immunoglobulin class-switch recombination in mice devoid of any S mu tandem repeat.; Khamlichi Ahmed; Glaudet Florence, Oruc Zeliha, Denis Vincent, Le Bert Marc, Cogné Michel; 2004; Blood; 103; 3828-36; 14962903
Availability:
- Frozen embryos. Delivered in 4 weeks. Price €1100.
- Rederivation of mice from frozen stock. Delivered in 4-6 months. Price €1700.
More detail on pricing and delivery times
Note:
Distribution of this strain is subject to a Material Transfer Agreement (MTA).
Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before frozen material or live mice can be shipped.