EMMA projects - European Conditional Mouse Mutagenesis Program (EUCOMM)
Objectives
Generation, archiving, and world-wide distribution of an ES cell resource containing up to 13000 conditional mutations across the mouse genome in mouse embryonic stem (ES) cells
Establishment, archiving, and world-wide distribution of up to 320 mouse mutants from this resource
Mutagenesis strategies
Conditional gene trapping - random approach for expressed genes
Conditional targeted trapping - directed approach, used for expressed genes
Conditional gene targeting - directed approach, used for non-expressed genes
Networking
Generation of a European mouse functional genomics platform through the integration of EMMA, EUMODIC, EURExpress, FLPFLEX, EMAGE, FunGenES, PRIME and other programmes
Member of the International Knockout Mouse Consortium (IKMC), acting as a cornerstone of world-wide mouse mutagenesis effort in collaboration with the Canadian (NorCOMM) and the U.S. (KOMP) programmes
Social benefits
Improvement of health research
Accelleration of clinical diagnosis, drug development and therapy
Competitive advantage for pharmaceutical industry
Funding & structure
Funded by European Union (FP 6)
EU funding: up to €13 million
Integrated Project
Consortium: 9 Participants from four European countries
EMMA will archive and distribute to the wider biomedical research community all 320 mouse mutant lines produced by EUCOMM. Targeting vectors and ES cells generated in the EUCOMM program are being distributed by EuMMCR.