EMMA partner
Wellcome Trust Sanger Institute, Hinxton, UK
Wellcome Trust Genome Campus
Hinxton
Cambridge CB10 1SA
United Kingdom
The Sanger Institute is a world-leading centre for genome-based biological research, based upon
high-throughput sequencing and bioinformatics as core underpinning technologies and using natural and
experimentally-induced variation (genetics) as tools to understand the function of the genome. We have
eight faculty groups working with the mouse, a new 22,000 cage mouse facility opened in May 2006, and
expertise in recombineering, ES cell production, mutant generation, and a wide range of phenotyping
techniques.
The Sanger Institute is an integral part of the international mouse knockout programme, funded largely by the EC (EUCOMM) and NIH (KOMP), and has established a new pipeline generating a library of ES cells with targeted mutations, producing conditional alleles when gene structure permits.
The large-scale Mouse Genetics Programme has established phenotyping pipelines for screening new mutant cohorts for signs of diseases of interest to our own Faculty and outside collaborators. We have established a Mouse Informatics Group to support the Mouse Genetics Programme and other mouse user needs, and this group has established electronic tracking and databases for several key aspects of the production and management of breeding and phenotyping of new mouse mutants.